SB lab

Under review:

• New Protein Variants Resulting from RNA Editing May Lead to Proteotoxic Stress. Adi Avram-Shperling* , Amit Ben-David* , Ms Michelle Eidelman , Mr Eli Kopel , Mr Orshay Gabay , Dr Galit David Kadoch , Joshua Rosenthal , Erez Levanon , *Eli Eisenberg, Shay Ben Aroya*. 

​​

 

 

Selected publications:

​

• A pipeline for identifying guide-RNA sequences that promote RNA- editing of nonsense mutations that cause inherited retinal diseases. Nina Schneider*, Ricky Steinberg*, Amit Eylon*, Johanna Valensi*, Galit Kadoch, Zohar Rosenwasser, Eyal Banin, Erez Y. Levanon, Dror Sharon*, Shay Ben-Aroya*. Molecular Therapy-Nucleic Acids 

​

•  Identification of exceptionally potent adenosine deaminases RNA editors from high body temperature organisms.​Avram-Shperling A, Kopel E, Twersky I, Gabay O, Ben-David A, Karako-Lampert S, Rosenthal JJC, Levanon EY, Eisenberg E, Ben-Aroya S. PLoS Genet. 2023 Mar 6;19(3)

​

• Inactive Proteasomes Routed to Autophagic Turnover Are Confined within the Soluble Fraction of the Cell.Friedman K, Karmon O, Fridman U, Goldberg Y, Pines O, Ben-Aroya S. Biomolecules. 2022 Dec 30;13(1):77. 

 

• Reversal of histone H2B mono-ubiquitination is required for replication stress recovery. Hadar Tzemach Korenfeld*, Adi Avram Shperling*, Yifat Zukerman, Anais Iluz, Hanna Boocholez, Lilach Ben-Shimon and Shay Ben-Aroya. DNA Repair (Amst). 2022 Aug 18;119:103387

 

• Inherited retinal diseases: Linking genes, disease-causing variants, and relevant therapeutic modalities. Schneider N, Sundaresan Y, Gopalakrishnan P, Beryozkin A, Hanany M, Levanon EY, Banin E, Ben-Aroya S, Sharon D. Prog Retin Eye Res. 2022 Jul;89:101029. Review.

​

• Spatial organization of proteasome aggregations regulates proteasome subunits homeostasis. Ofri Karmon, and Shay Ben-Aroya. Front Mol Biosci. 2020 Jan 9;6:150.

 

• Regulation of the Anaphase Promoting Complex/Cyclosome by the Degradation of its Unassembled Catalytic Subunit, Apc11. Volpe M, Levinton N, Rosenstein N, Prag G, Ben-Aroya S. FASEB J. 2019 Sep;33(9):9752-9761.

 

• Fe-S cluster coordination of the chromokinesin KIF4A alters its subcellular localization during mitosis. Ben-Shimon L, Paul VD, David-Kadoch G, Volpe M, Stümpfig M, Bill E, Mühlenhoff U, Lill R, Ben-Aroya S. J Cell Sci. 2018 Jun 27;131(12).

 

• A-to-I RNA Editing: An Overlooked Source of Cancer Mutations. Ben-Aroya S*, Levanon EY*. Cancer Cell. 2018 May 14;33(5):789-790.*Co-corresponding authors

 

• A New Method, "Reverse Yeast Two-Hybrid Array" (RYTHA), Identifies Mutants that Dissociate the Physical Interaction Between Elg1 and Slx5. Lev I, Shemesh K, Volpe M, Sau S, Levinton N, Molco M, Singh S, Liefshitz B, Ben Aroya S*, Kupiec M*. Genetics. 2017 Jul;206(3):1683-1697. doi: 10.1534/genetics.117.200451. Epub 2017 May 5. *Co-corresponding authors

 

•  A bacterial genetic selection system for ubiquitylation cascade discovery. Levin-Kravets O, Tanner N, Shohat N, Attali I, Keren-Kaplan T, Shusterman A, Artzi S, Varvak A, Reshef Y, Shi X, Zucker O, Baram T, Katina C, Pilzer I, Ben-Aroya S, Prag G. Nat Methods. Nov;13(11):945-952. (2016)

 

• Structure of ubiquitylated-Rpn10 provides insight into its autoregulation mechanism. Keren-Kaplan T, Zeev Peters L, Levin-Kravets O, Attali I, Kleifeld O, Shohat N, Artzi S, Zucker O, Pilzer I, Reis N, Glickman MH, Ben-Aroya S, Prag G. Nat Commun. Oct 4;7:12960. (2016)

 

• Proteasome storage granules are transiently associated with the insoluble protein deposit in Saccharomyces cerevisiae. Peters LZ, Karmon O, Miodownik S, Ben-Aroya S. J Cell Sci. Mar 15;129(6):1190-7. (2016)

​

• Lee Zeev Peters*, Ofri Karmon*, Rotem Hazan , and Ben-Aroya S. The protein quality control machinery regulates its misassembled proteasome subunits, and distinguishes them from proteasome storage granules. PLOS Genet. (2015)

 

• Lev I, Volpe M, Ben-Aroya S. Systematic identification of genes that mediate the physical interaction between protein pairs in the yeast Saccharomyces cerevisiae. Curr Protoc Cell Biol. Sep 2;64 (2014) (Book Chapter).

 

• Telomere length kinetics assay (TELKA) sorts the telomere length maintenance (tlm) mutants into functional groups. Rubinstein L, Ungar L, Harari Y, Babin V, Ben-Aroya S, Merenyi G, Marjavaara L, Chabes A, Kupiec M. Nucleic Acids Res, 42(10):6314-25. (2014)

 

• Lev I, Volpe M, Goor L, Levinton N, Emuna L, Ben-Aroya S. Reverse PCA, a Systematic Approach for Identifying Genes Important for the Physical Interaction between Protein Pairs. PLOS Genet. (2013)

 

• Peters LZ, Hazan R, Breker M, Schuldiner M, Ben-Aroya S. Formation and dissociation of proteasome storage granules are regulated by cytosolic pH. J Cell Biol. May 27;201(5):663-71. (2013). Has been selected for F1000Prime (recommended as being of special significance in its field, (http://f1000.com/prime/718019946?bd=1&ui=154432))

 

• Ben-Aroya S. The proteasome activator PA28γ is a novel component of the DNA double-strand break response network. Cell Cycle, Feb 1;11(3):435-6. (2012)

 

• Stirling PC, Bloom MS, Solanki-Patil T, Smith S, Sipahimalani P, Li Z, Kofoed M, Ben-Aroya S, Myung K, Hieter P. The complete spectrum of yeast chromosome instability genes identifies candidate CIN cancer genes and functional roles for ASTRA complex components. PLOS Genet. (2011) 

 

• Fridman Y, Palgi N, Dovrat D, Ben-Aroya S, Hieter P, Aharoni A.Subtle alterations in PCNA-partner interactions severely impair DNA replication and repair. PLoS Biol. (2010)

​

• Parnas O, Zipin-Roitman A, Pfander B, Liefshitz B, Mazor Y, Ben-Aroya S, Jentsch S, Kupiec M. Elg1, an alternative subunit of the RFC clamp loader, preferentially interacts with SUMOylated PCNA. EMBO J. Aug 4;29(15):2611-22. (2010)

 

• Shay Ben-Aroya, Neta Agmon, Karen Yuen, Kirk McManus, Martin Kupiec, and Philip Hieter. Proteasome nuclear activity affects chromosome stability by controlling the turnover of Mms22, a protein important for DNA repair.  PLoS Genetics. (2010)

 

• Shay Ben-Aroya, Pan X, Boeke JD, Hieter P. Making temperature-sensitive mutants. Methods in Enzymology, 470:181-204. (2010)

 

• Shay Ben-Aroya, Candice Coombes,  Teresa Kwok,  Jef D. Boeke, and Philip Hieter. Towards a comprehensive temperature sensitive mutant repository for all essential genes of the yeast Saccharomyces cerevisiae. Molecular Cell, Apr 25;30(2):248-58. (2008)

​

• Shay Ben-Aroya, Michkovski P., Petes T.D. and Kupiec M. The compact chromatin structure of Ty repeated sequence suppresses recombination hotspot activity in Saccharomyces cerevisiae. Molecular Cell, Jul 23; 15(2):221-31 (2004)

 

• Shay Ben-Aroya, Koren A., Liefshitz B., Steinlauf R.and Kupiec M. ELG1, a yeast gene required for genome stability, forms a complex related to Replication Factor C. Proc. Natl. Acad. Sci. USA 100(17): 9906-9911. (2003)